Effect of lyophilized extracts from guaraná seeds [Paullinia cupana var. sorbilis (Mart.) Ducke] on behavioral profiles in rats

• Published in: Phytotherapy research Vol. 21; no. 6; pp. 531 - 535
• Main Authors: Otobone, F. J., Sanches, A. C. C., Nagae, R., Martins, J. V. C., Sela, V. R., Mello, J. C. P. de, Audi, E. A.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.06.2007; Wiley
• Subjects: Animals; antidepressant-like effect; Antidepressive Agents - chemistry; Antidepressive Agents - pharmacology; Behavior, Animal - drug effects; Biological and medical sciences; Dose-Response Relationship, Drug; elevated plus maze; forced swimming test; Freeze Drying; General pharmacology; Guaraná; Male; Maze Learning - drug effects; Medical sciences; Motor Activity - drug effects; Paullinia - chemistry; Paullinia cupana; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - chemistry; Plant Extracts - pharmacology; Rats; Rats, Wistar; Sapindaceae; Seeds - chemistry; Seeds; Rat; Pharmacognosy; Psychotropic; Rodentia; forced swimming test; Stimulant plant; Extract; elevated plus maze; Medicinal plant; Vertebrata; Mammalia; Dicotyledones; Animal; Angiospermae; Plant origin; Sapindaceae; Guaraná; Antidepressant agent; Spermatophyta; antidepressant-like effect; Paullinia cupana
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.2089

The aim of the present study was to investigate the pharmacological properties of the crude lyophilized extract (EBPC) of Paullinia cupana seeds (guaraná) and the semi‐purified extracts (EPA and EPB) after acute or chronic administration by the oral route in rats. Anxiolytic‐like, antidepressant‐like and motor stimulant effects were evaluated using the plus maze (PMT), forced swimming (FST) and open field (OFT) tests, respectively. Acute or chronic administration of EBPC (3.0, 30.0 or 60.0 mg/kg) did not alter the percentage of entries or the time spent in the open arm in the PMT. In the FST, chronic treatment with 30.0 mg EBPC/kg and 4.0 mg EPA/kg extract decreased the immobility time similarly to the antidepressant reference drug, imipramine (20.0 mg/kg). Locomotor activity in the OFT was not increased by these extracts. Caffeine (10.0 mg/kg) significantly reduced the immobility time in the FST, but increased locomotor activity in the OFT, indicating psychostimulant activity. The EPB extract did not induce any effect after acute or chronic treatment in the different models used. The present results suggest that the crude EBPC extract and EPA extract produced an antidepressant‐like effect after long‐term administration. Copyright © 2007 John Wiley & Sons, Ltd.