ANTIBIOTICS FROM BASIDIOMYCETES XXXVIII. 2-METHOXY-5-METHYL-1, 4-BENZOQUINONE, A THROMBOXANE A2 RECEPTOR ANTAGONIST FROM LENTINUS ADHAERENS

• Published in: Journal of antibiotics Vol. 44; no. 1; pp. 59 - 65
• Main Authors: LAUER, URSULA, ANKE, TIMM, HANSSKE, FRITZ
• Format: Journal Article
• Language: English
• Published: Japan JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1991
• Subjects: Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Basidiomycota - metabolism; Benzoquinones - chemistry; Benzoquinones - isolation & purification; Benzoquinones - pharmacology; Fermentation; Fibrinolytic Agents - chemistry; Fibrinolytic Agents - isolation & purification; Fibrinolytic Agents - pharmacology; Humans; Molecular Structure; Platelet Aggregation Inhibitors - chemistry; Platelet Aggregation Inhibitors - isolation & purification; Platelet Aggregation Inhibitors - pharmacology; Receptors, Prostaglandin - drug effects; Receptors, Thromboxane; Thromboxanes - antagonists & inhibitors; Thromboxanes - metabolism
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.44.59

In the course of our screening for antithrombotic compounds using platelet rich plasma from bovine slaughter blood, 2-methoxy-5-methyl-1, 4-benzoquinone (1) has been isolated from mycelial cultures of Lentinus adhaerens. The compound inhibits the U46619-induced aggregation of human blood platelets with an IC50 of 2.5 μg/ml (16.45 μM) and is a new thromboxane A2 receptor antagonist. This is the first report on an inhibitor of platelet aggregation derived from secondary metabolism of basidiomycetes.