Rapid Development of Achalasia After SARS-CoV-2 Infection: Polymerase Chain Reaction Analysis of Esophageal Muscle Tissue
INTRODUCTION:Achalasia has been linked to viruses. We have observed cases of rapid-developing achalasia post-coronavirus disease 2019 (COVID-19).METHODS:We aimed to prospectively evaluate esophageal muscle for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from patients with rapid-onse...
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| Published in | The American journal of gastroenterology Vol. 119; no. 5; pp. 987 - 990 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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Philadelphia, PA
Wolters Kluwer
01.05.2024
Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins |
| Subjects | |
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| Abstract | INTRODUCTION:Achalasia has been linked to viruses. We have observed cases of rapid-developing achalasia post-coronavirus disease 2019 (COVID-19).METHODS:We aimed to prospectively evaluate esophageal muscle for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from patients with rapid-onset achalasia post-COVID-19 and compare them with achalasia predating COVID-19 and achalasia with no COVID-19.RESULTS:Compared with long-standing achalasia predating COVID-19 and long-standing achalasia with no COVID-19, the subjects with achalasia post-COVID-19 had significantly higher levels of messenger RNA for the SARS-CoV-2 nucleocapsid (N) protein, which correlated with a significant increase in the inflammatory markers NOD-like receptor family pyrin domain-containing 3 and tumor necrosis factor.DISCUSSION:SARS-CoV-2, the virus responsible for COVID-19, is a possible trigger for achalasia. |
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| AbstractList | INTRODUCTION:Achalasia has been linked to viruses. We have observed cases of rapid-developing achalasia post-coronavirus disease 2019 (COVID-19).METHODS:We aimed to prospectively evaluate esophageal muscle for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from patients with rapid-onset achalasia post-COVID-19 and compare them with achalasia predating COVID-19 and achalasia with no COVID-19.RESULTS:Compared with long-standing achalasia predating COVID-19 and long-standing achalasia with no COVID-19, the subjects with achalasia post-COVID-19 had significantly higher levels of messenger RNA for the SARS-CoV-2 nucleocapsid (N) protein, which correlated with a significant increase in the inflammatory markers NOD-like receptor family pyrin domain-containing 3 and tumor necrosis factor.DISCUSSION:SARS-CoV-2, the virus responsible for COVID-19, is a possible trigger for achalasia. Achalasia has been linked to viruses. We have observed cases of rapid-developing achalasia post-coronavirus disease 2019 (COVID-19). We aimed to prospectively evaluate esophageal muscle for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from patients with rapid-onset achalasia post-COVID-19 and compare them with achalasia predating COVID-19 and achalasia with no COVID-19. Compared with long-standing achalasia predating COVID-19 and long-standing achalasia with no COVID-19, the subjects with achalasia post-COVID-19 had significantly higher levels of messenger RNA for the SARS-CoV-2 nucleocapsid (N) protein, which correlated with a significant increase in the inflammatory markers NOD-like receptor family pyrin domain-containing 3 and tumor necrosis factor. SARS-CoV-2, the virus responsible for COVID-19, is a possible trigger for achalasia. Achalasia has been linked to viruses. We have observed cases of rapid-developing achalasia post-coronavirus disease 2019 (COVID-19).INTRODUCTIONAchalasia has been linked to viruses. We have observed cases of rapid-developing achalasia post-coronavirus disease 2019 (COVID-19).We aimed to prospectively evaluate esophageal muscle for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from patients with rapid-onset achalasia post-COVID-19 and compare them with achalasia predating COVID-19 and achalasia with no COVID-19.METHODSWe aimed to prospectively evaluate esophageal muscle for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from patients with rapid-onset achalasia post-COVID-19 and compare them with achalasia predating COVID-19 and achalasia with no COVID-19.Compared with long-standing achalasia predating COVID-19 and long-standing achalasia with no COVID-19, the subjects with achalasia post-COVID-19 had significantly higher levels of messenger RNA for the SARS-CoV-2 nucleocapsid (N) protein, which correlated with a significant increase in the inflammatory markers NOD-like receptor family pyrin domain-containing 3 and tumor necrosis factor.RESULTSCompared with long-standing achalasia predating COVID-19 and long-standing achalasia with no COVID-19, the subjects with achalasia post-COVID-19 had significantly higher levels of messenger RNA for the SARS-CoV-2 nucleocapsid (N) protein, which correlated with a significant increase in the inflammatory markers NOD-like receptor family pyrin domain-containing 3 and tumor necrosis factor.SARS-CoV-2, the virus responsible for COVID-19, is a possible trigger for achalasia.DISCUSSIONSARS-CoV-2, the virus responsible for COVID-19, is a possible trigger for achalasia. |
| Author | Hamza, Ameer Kahrilas, Peter J. Wozniak, Ann Samo, Salih Hamo, Falak Yadlapati, Rena |
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| Cites_doi | 10.14309/ajg.0000000000000691 10.1111/nmo.14104 10.1053/j.gastro.2020.11.026 10.1053/j.gastro.2021.04.057 10.1038/s41577-019-0131-x 10.1016/j.cgh.2016.08.030 10.1038/s41590-021-01095-w 10.1038/s41467-021-25509-3 10.1111/nmo.14502 10.1111/nmo.14314 10.1111/jgh.15717 10.1097/SLA.0000000000004004 10.1053/j.gastro.2020.02.055 |
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| Keywords | COVID-19 SARS-CoV-2 achalasia |
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| Notes | Correspondence: Salih Samo, MD, MS. E-mail: ssamo@kumc.edu.SUPPLEMENTARY MATERIAL accompanies this paper at http://links.lww.com/AJG/D167 and http://links.lww.com/AJG/D168 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
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| Snippet | INTRODUCTION:Achalasia has been linked to viruses. We have observed cases of rapid-developing achalasia post-coronavirus disease 2019 (COVID-19).METHODS:We... Achalasia has been linked to viruses. We have observed cases of rapid-developing achalasia post-coronavirus disease 2019 (COVID-19). We aimed to prospectively... INTRODUCTION:Achalasia has been linked to viruses. We have observed cases of rapid-developing achalasia post–coronavirus disease 2019 (COVID-19).METHODS:We... Achalasia has been linked to viruses. We have observed cases of rapid-developing achalasia post-coronavirus disease 2019 (COVID-19).INTRODUCTIONAchalasia has... |
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| SubjectTerms | Adult Aged Asymptomatic Biopsy Chicken pox Coronavirus Nucleocapsid Proteins COVID-19 - complications COVID-19 vaccines Cytokines Esophageal Achalasia - virology Esophagus Esophagus - virology Female Gastroenterology Humans Immunoglobulins Infections Inflammation Inflammatory bowel disease Male Middle Aged Pharmaceuticals Phosphoproteins - metabolism Polymerase chain reaction Polymerase Chain Reaction - methods Prospective Studies Proteins RNA, Messenger - metabolism SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Viral infections |
| Title | Rapid Development of Achalasia After SARS-CoV-2 Infection: Polymerase Chain Reaction Analysis of Esophageal Muscle Tissue |
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