Precision study of DXA-based patient-specific finite element modeling for assessing hip fracture risk

• Published in: International journal for numerical methods in biomedical engineering Vol. 29; no. 5; pp. 615 - 629
• Main Authors: Luo, Yunhua, Ferdous, Zannatul, Leslie, William D.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.05.2013; Wiley Subscription Services, Inc
• Subjects: Absorptiometry, Photon - methods; Adult; Aged; Aged, 80 and over; Anthropometry - methods; DXA-based finite element model; Female; Femur - diagnostic imaging; Finite Element Analysis; hip fracture risk; Hip Fractures - diagnostic imaging; Humans; Image Processing, Computer-Assisted - methods; Middle Aged; Osteoporosis; precision; Reproducibility of Results; Risk Assessment - methods
• ISSN: 2040-7939; 2040-7947; 2040-7947
• DOI: 10.1002/cnm.2548

SUMMARYFinite element (FE) modeling based on a patient's hip dual energy X‐ray absorptiometry (DXA) image is a promising tool for more accurately assessing hip fracture risk, as it is able to comprehensively consider effects from all the mechanical parameters affecting hip fracture. However, a number of factors influence the precision (also known as repeatability or reproducibility) of a DXA‐based FE procedure, for example, subject positioning in DXA scanning. As a procedure is required to have adequately high precision in clinical application, we investigated the effects of the involved factors on the precision of a DXA‐based patient‐specific FE procedure developed by the authors, to provide insight into how the precision of the procedure can be improved so that it can meet the clinical standards. Fracture risk indices corresponding to initial and repeat DXA scans acquired in 30 typical clinical subjects were computed and compared to assess short term repeatability of the procedure. It was found that inconsistent positioning followed by manual segmentation of the projected femur contour induced significant variability in the predicted fracture risk indices. This research suggests that, to apply the DXA‐based FE procedure in clinical assessment, it will be necessary to pay more strict attention to subject positioning in DXA scanning. Copyright © 2013 John Wiley & Sons, Ltd. Key Findings: Precision of DXA‐based finite element modeling procedure for assessing hip fracture risk was studied for the first time. Effects of factors affecting the precision were successfully isolated, which provides insight into the question why a DXA‐based finite element procedure sounds more reasonable for assessing hip fracture risk than areal bone mineral density alone but has not established its role in clinical applications. The research outcome provides a clear way for improving the precision of a DXA‐based finite element procedure so that it will meet clinical requirements.