Failure of multiplex meningitis/encephalitis (ME) NAT during cryptococcal meningitis in solid organ recipients

Cryptococcal meningitis is a severe cause of central nervous system infections among immunocompromised solid organ transplant (SOT) patients. While new diagnostic methods as multiplex meningitis/encephalitis (ME) NAT (nucleic acid test) are increasingly used as a first‐line tool in hospital practice...

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Published inTransplant infectious disease Vol. 22; no. 4; pp. e13263 - n/a
Main Authors Pilmis, Benoit, Bougnoux, Marie‐Elizabeth, Guery, Romain, Senghor, Yaye, Le Monnier, Alban, Lanternier, Fanny, Bretagne, Stephane, Alanio, Alexandre, Lortholary, Olivier
Format Journal Article
LanguageEnglish
Published Denmark Wiley Subscription Services, Inc 01.08.2020
Wiley
Subjects
Bacteriology
Central nervous system
Cryptococcus sp
Diagnostic systems
Ecology, environment
Encephalitis
Fungal infections
Health
HIV
Human health and pathology
Human immunodeficiency virus
Infectious diseases
Life Sciences
Meningitis
meningitis/meningoencephalitis
Microbiology and Parasitology
multiplex PCR
Multiplexing
Nucleic acids
Santé publique et épidémiologie
Virology
multiplex PCR
meningitis/meningoencephalitis
Cryptococcus sp
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Summary:Cryptococcal meningitis is a severe cause of central nervous system infections among immunocompromised solid organ transplant (SOT) patients. While new diagnostic methods as multiplex meningitis/encephalitis (ME) NAT (nucleic acid test) are increasingly used as a first‐line tool in hospital practice, data in HIV‐negative patients including SOT remain scarce. We report here false‐negative results of multiplex NAT among SOT patients with proven cryptococcal meningitis.
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ISSN:1398-2273
1399-3062
DOI:10.1111/tid.13263