Successful therapy of crystalcryoglobulinemia: a case report

Successful therapy for a case of multiple myeloma with a spontaneously crystallizing cryoglobulin of the IgG2-kappa light chain variety was achieved, using both continuous-flow cell centrifugation plasmapheresis to rapidly lower the M component and combination chemotherapy with phenylalanine mustard...

Full description

Saved in:
Bibliographic Details
Published inMedical and pediatric oncology Vol. 7; no. 2; p. 181
Main Authors Cummings, F J, Park, C H, Bogaars, H A, Kalderon, A E, Melnicoff, I, Kaplan, S R, Diamond, I, Calabresi, P
Format Journal Article
LanguageEnglish
Published United States 1979
Subjects
Antineoplastic Agents - administration & dosage
Cryoglobulins
Crystallization
Drug Therapy, Combination
Humans
Immunoglobulin G
Immunoglobulin kappa-Chains
Male
Middle Aged
Multiple Myeloma - immunology
Multiple Myeloma - pathology
Multiple Myeloma - therapy
Plasmapheresis
Online AccessGet more information

Cover

More Information
Summary:Successful therapy for a case of multiple myeloma with a spontaneously crystallizing cryoglobulin of the IgG2-kappa light chain variety was achieved, using both continuous-flow cell centrifugation plasmapheresis to rapidly lower the M component and combination chemotherapy with phenylalanine mustard, prednisone, procarbazine, and vincristine to control the myeloma process. This resulted in resolution of incapacitating large and small necrotic cutaneous ulcerations of the extremities. Physicochemical studies of the crystalcryoprotein demonstrated that cryoprecipitation was rapid and accompanied by the formation of needle-shaped crystals, yet was completely reversible at 37 degrees C. Cryocrit determinations varied depending upon relative centrifugal forces and temperature and did not always relate linearly to the amount of abnormal protein, thus making these alone unreliable in assessing response to therapy.
ISSN:0098-1532
1096-911X
DOI:10.1002/mpo.2950070213