Antioxidant properties and xanthine oxidase inhibitory effects of Tamus communis L. root extracts
This study was conducted to search for xanthine oxidase (XO) inhibitors from the root extracts of Tamus communis L. traditionally used in folk medicine in Algeria. Root extracts with different solvents were screened for purified milk xanthine oxidase inhibition. The root extracts (methanol, chlorofo...
Saved in:
Published in | Phytotherapy research Vol. 23; no. 2; pp. 283 - 288 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Chichester, UK
John Wiley & Sons, Ltd
01.02.2009
Wiley |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | This study was conducted to search for xanthine oxidase (XO) inhibitors from the root extracts of Tamus communis L. traditionally used in folk medicine in Algeria. Root extracts with different solvents were screened for purified milk xanthine oxidase inhibition. The root extracts (methanol, chloroform and ethyl acetate) and proteins, obtained in distilled water, inhibited bovine, sheep and human milk XO from three species in a concentration‐dependent manner, with an additional superoxide scavenging capacity, which reached its highest level with ethyl acetate extract (IC50 = 0.15, 0.04 and 0.09 g/L) for bovine XO, sheep XO and human XO, respectively. The antioxidant potential was confirmed with the non‐enzymatic method, total radical‐trapping antioxidant parameter (TRAP) assay, which showed that the Tamus communis L. extracts have a potential antioxidant activity in the same order obtained by using the reduction of cytochrome c, an enzymatic method, in which the antioxidant activity followed a decreasing order: ethyl acetate extract > chloroform extract > protein. Copyright © 2008 John Wiley & Sons, Ltd. |
---|---|
Bibliography: | Algerian Agency for the Development of Research in Health (ANDRS) istex:62E91405E7FC69963E3621015CAF04B8D82FCA4F ark:/67375/WNG-T82DC8XK-S ArticleID:PTR2621 Algerian Ministry of Higher Education and Scientific Research (MERS) ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0951-418X 1099-1573 |
DOI: | 10.1002/ptr.2621 |