5-Fluorouracil neurotoxicity

Two cases of 5-fluorouracil-induced neurotoxicity from the University of North Carolina are presented. 5-Fluorouracil metabolism is briefly discussed with reference to possible mechanisms for the neurotoxicity. A possible role for thiamine supplementation in the prevention of this unusual complicati...

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Bibliographic Details
Published inGynecologic oncology Vol. 36; no. 1; pp. 152 - 154
Main Authors Moore, David H., Fowler, Wesley C., Crumpler, Linda S.
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 1990
Elsevier
Subjects
Adult
Biological and medical sciences
Carcinoma, Squamous Cell - drug therapy
Drug toxicity and drugs side effects treatment
Female
Fluorouracil - adverse effects
Fluorouracil - metabolism
Humans
Medical sciences
Middle Aged
Nervous System Diseases - chemically induced
Pharmacology. Drug treatments
Thiamine Deficiency - complications
Toxicity: nervous system and muscle
Uterine Cervical Neoplasms - drug therapy
Antineoplastic agent
Case study
Human
Prevention
Nervous system diseases
Toxicity
Vitamin
Female
Nervous system
Thiamin
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Summary:Two cases of 5-fluorouracil-induced neurotoxicity from the University of North Carolina are presented. 5-Fluorouracil metabolism is briefly discussed with reference to possible mechanisms for the neurotoxicity. A possible role for thiamine supplementation in the prevention of this unusual complication is supported by our experience.
ISSN:0090-8258
1095-6859
DOI:10.1016/0090-8258(90)90127-7