Spinal cord compression in Paget's disease of bone with reference to sarcomatous degeneration and calcitonin treatment

• Published in: Surgical neurology Vol. 27; no. 2; pp. 117 - 125
• Main Authors: Gruszkiewicz, J., Doron, Y., Borovich, B., Zaaroor, M.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.1987; Elsevier
• Subjects: Aged; Biological and medical sciences; Calcitonin; Calcitonin - therapeutic use; Computed tomography scanning; Decompressive laminectomy; Diseases of the osteoarticular system; Humans; Male; Medical sciences; Middle Aged; Osteitis Deformans - complications; Osteitis Deformans - diagnostic imaging; Osteitis Deformans - drug therapy; Osteitis Deformans - pathology; Osteoporosis. Osteomalacia. Paget disease; Paget's disease of vertebrae; Sarcoma - complications; Sarcoma - diagnostic imaging; Sarcoma - pathology; Sarcomatous degeneration; Spinal cord compression; Spinal Cord Compression - complications; Spinal Cord Compression - surgery; Spinal Neoplasms - complications; Spinal Neoplasms - diagnostic imaging; Spinal Neoplasms - pathology; Tomography, X-Ray Computed; Sarcomatous degeneration; Decompressive laminectomy; Paget's disease of vertebrae; Calcitonin; Computed tomography scanning; Spinal cord compression; Human; Chemotherapy; Spinal cord; Paget disease of bone; Nervous system diseases; Metabolic disorder; Malignant transformation; Diseases of the osteoarticular system; Commission; Bone disease
• ISSN: 0090-3019; 1879-3339
• DOI: 10.1016/0090-3019(87)90282-5

Four cases of spinal cord compression stemming from Paget's disease of bone tissue are reported. Sarcomatous degeneration was proved in one case and in another one malignancy was deduced by computed tomography (CT) scanning. Clinical and radiologic manifestations as well as surgical management are discussed. The value of CT scanning of the spine as an aid in the evaluation of structural changes and the size of the soft tissue mass in sarcomatous degeneration of the lesion is stressed. After calcitonin administration, alleviation of pain and improvement in neurological status have occurred in two treated patients.