Lipid intolerance does not account for susceptibility to alcoholic and gallstone pancreatitis

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 106; no. 3; p. 742
• Main Authors: Haber, P S, Wilson, J S, Apte, M V, Hall, W, Goumas, K, Pirola, R C
• Format: Journal Article
• Language: English
• Published: United States 01.03.1994
• Subjects: Alcoholism - blood; Alcoholism - complications; Apolipoproteins E - analysis; Apolipoproteins E - genetics; Cholelithiasis - blood; Cholelithiasis - complications; Disease Susceptibility; Ethanol - pharmacology; Female; Follow-Up Studies; Humans; Lipids - physiology; Male; Middle Aged; Multivariate Analysis; Pancreatitis - blood; Pancreatitis - etiology; Phenotype; Triglycerides - blood
• ISSN: 0016-5085
• DOI: 10.1016/0016-5085(94)90710-2

Hypertriglyceridemia is an established cause of pancreatitis and has been suggested as a predisposing factor in alcohol and gallstone-induced pancreatitis. The aims of this study were to determine fasting and postprandial triglyceride levels of alcoholics with pancreatitis, alcoholics without pancreatitis, patients with previous gallstone pancreatitis, patients with choledocholithiasis, and healthy controls. Oral lipid tolerance studies were performed in the above groups. No relationship was found between alcoholic pancreatitis and hypertriglyceridemia, regardless of whether subjects were studied in the fasting state, after ingestion of fat, or after ingestion of fat with ethanol. Plasma triglyceride levels of alcoholics with pancreatitis remained similar to those of alcoholics without pancreatitis, but levels in both groups varied in relation to recent alcohol intake. Plasma triglyceride levels from both groups of alcoholics were greater than those of nonalcoholic healthy subjects. In addition, the previously reported association between postprandial hypertriglyceridemia and gallstone pancreatitis was not observed. Plasma triglyceride levels do not account for individual susceptibility to either alcoholic or gallstone pancreatitis.