Vaginal administration of a combined oral contraceptive containing norethisterone acetate

• Published in: Contraception (Stoneham) Vol. 31; no. 6; pp. 571 - 581
• Main Authors: Souka, Abdel Razak, Kamel, Moustafa, Einen, Moustafa A., Saleh, Fawzia, Sallam, Hassan
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.06.1985; Elsevier Science
• Subjects: Adult; Biological and medical sciences; Birth control; Clinical Trials as Topic; Contraceptives, Oral, Combined - administration & dosage; Contraceptives, Oral, Combined - adverse effects; Endometrium - cytology; Endometrium - drug effects; Ethinyl Estradiol - administration & dosage; Ethinyl Estradiol - adverse effects; Fatigue - chemically induced; Female; Gynecology. Andrology. Obstetrics; Humans; Medical sciences; Norethindrone - administration & dosage; Norethindrone - adverse effects; Norethindrone - analogs & derivatives; Norethindrone Acetate; Other methods of contraception. Sterilization; Ovulation - drug effects; Progesterone - blood; Vagina; Ethinylestradiol; Human; Vaginal route; Estroprogestagen; Synthetic product; Gynecology; Contraceptive; Norethisterone; Sex steroid hormone; Route of administration; Norethindrone Acetate; Contraceptive Agents, Progestin; Contraceptive Agents > administraction and dosage; Oral Contraceptives > side effects; Reproductive Control Agents; Contraceptive Agents, Estrogen; Contraceptive Methods > administraction and dosage; Biology; Contraception; Hormones; Contraceptive Methods > side effects; Ethinyl Estradiol; Family Planning; Research Methodology; Endocrine System; Diseases; Norethindrone; Contraceptive Agents, Female > administraction and dosage; Clinical Research; Oral Contraceptives > administraction and dosage; Physiology; Metabolic Effects
• ISSN: 0010-7824; 1879-0518
• DOI: 10.1016/0010-7824(85)90057-5

The effects of vaginal administration of an oral contraceptive pill containing 1mg of norethisterone acetate and 0.05 mg of ethinyl oestradiol were studied in 20 subjects for a total ot 57 cycles. The results show effective ovulation suppression in the two dose regimens used. The lower dose regimen was associated with fewer side effects and no breakthrough bleeding. No significant change was observed in the serum concentration of glucose, total proteins, albumin, cholesterol and HDL after several cycles of treatment in both dose regimens used. It is concluded that vaginal administration of this preparation of oral contraceptives is an effective alternative method of hormonal contraception.