The effect of myometrial contractures on uterine blood flow in the pregnant sheep at 114 to 140 days' gestation measured by the 4-aminoantipyrine equilibrium diffusion technique

Uterine blood flow, between 114 and 140 days' gestation, measured by the 4-aminoantipyrine equilibrium diffusion technique, was significantly decreased from 1359.1 +/- 84.4 ml X min-1 (mean +/- SE) in the absence of contractures to 1147.4 +/- 71.8 ml X min-1 (mean +/- SE) during a contracture (...

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Bibliographic Details
Published inAmerican journal of obstetrics and gynecology Vol. 149; no. 4; p. 408
Main Authors Sunderji, S G, El Badry, A, Poore, E R, Figueroa, J P, Nathanielsz, P W
Format Journal Article
LanguageEnglish
Published United States 15.06.1984
Subjects
Ampyrone - pharmacology
Animals
Carbon Dioxide - blood
Female
Fetus - drug effects
Hydrogen-Ion Concentration
Oxygen - blood
Posture
Pregnancy
Sheep
Uterine Contraction
Uterus - blood supply
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Summary:Uterine blood flow, between 114 and 140 days' gestation, measured by the 4-aminoantipyrine equilibrium diffusion technique, was significantly decreased from 1359.1 +/- 84.4 ml X min-1 (mean +/- SE) in the absence of contractures to 1147.4 +/- 71.8 ml X min-1 (mean +/- SE) during a contracture (p less than 0.01). Contractures reduced total uterine blood flow regardless of whether the ewe was standing or lying. These observations are in keeping with the suggestion that changes in total uterine blood flow may be an important mechanism responsible for the previously described temporal relationship between contractures and fetal neurophysiologic function.
ISSN:0002-9378
DOI:10.1016/0002-9378(84)90155-8