Structure and Photosensitaizer Ability of Polymethine Dyes in Photodynamic Therapy: A Review

Different approaches to the development of promising photosensitizers based on polymethine dyes (PD) for photodynamic therapy are systematized, summarized, and analyzed. PD of the near-IR spectral range has drawn special attention. The influence of a heavy atom (chalcogens, halogens, and noble metal...

Full description

Saved in:
Bibliographic Details
Published inTheoretical and experimental chemistry Vol. 58; no. 6; pp. 373 - 401
Main Authors Ishchenko, A. A., Syniugina, A. T.
Format Journal Article
LanguageEnglish
Published New York Springer US 2023
Springer
Springer Nature B.V
Subjects
Active oxygen
Cancer
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chromophores
Dyes
Electron transfer
Free radicals
Halogens
Hypoxia
Noble metals
Photochemotherapy
Photodynamic therapy
Singlet oxygen
polymethine dyes
free radicals
photosensitizers
singlet oxygen
photodynamic therapy
spectral-luminescent properties
Online AccessGet full text

Cover

More Information
Summary:Different approaches to the development of promising photosensitizers based on polymethine dyes (PD) for photodynamic therapy are systematized, summarized, and analyzed. PD of the near-IR spectral range has drawn special attention. The influence of a heavy atom (chalcogens, halogens, and noble metals), the chromophore interaction, electron transfer, and free radicals on the singlet oxygen generation by PD is discussed. The PD photodynamic activity mechanisms under hypoxia conditions are considered. The PD structural modifications that ensure their targeted delivery to cancer cells are analyzed.
ISSN:0040-5760
1573-935X
DOI:10.1007/s11237-023-09754-9