Structure and Photosensitaizer Ability of Polymethine Dyes in Photodynamic Therapy: A Review
Different approaches to the development of promising photosensitizers based on polymethine dyes (PD) for photodynamic therapy are systematized, summarized, and analyzed. PD of the near-IR spectral range has drawn special attention. The influence of a heavy atom (chalcogens, halogens, and noble metal...
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Published in | Theoretical and experimental chemistry Vol. 58; no. 6; pp. 373 - 401 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
New York
Springer US
2023
Springer Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Different approaches to the development of promising photosensitizers based on polymethine dyes (PD) for photodynamic therapy are systematized, summarized, and analyzed. PD of the near-IR spectral range has drawn special attention. The influence of a heavy atom (chalcogens, halogens, and noble metals), the chromophore interaction, electron transfer, and free radicals on the singlet oxygen generation by PD is discussed. The PD photodynamic activity mechanisms under hypoxia conditions are considered. The PD structural modifications that ensure their targeted delivery to cancer cells are analyzed. |
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ISSN: | 0040-5760 1573-935X |
DOI: | 10.1007/s11237-023-09754-9 |