Mesenchymal niches of bone marrow in cancer

• Published in: Clinical & translational oncology Vol. 13; no. 9; pp. 611 - 616
• Main Authors: Abarrategi, Ander, Mariñas-Pardo, Luis, Mirones, Isabel, Rincón, Esther, García-Castro, Javier
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 01.09.2011
• Subjects: Animals; Antineoplastic Agents - pharmacology; Bone Marrow Cells - drug effects; Bone Marrow Cells - pathology; Bone Marrow Cells - physiology; Drug Resistance, Neoplasm - physiology; Educational Series/Green Series; Humans; Medicine; Medicine & Public Health; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - drug effects; Mesenchymal Stromal Cells - pathology; Mesenchymal Stromal Cells - physiology; Neoplasm Metastasis; Neoplasms - drug therapy; Neoplasms - pathology; Oncology; Stem Cell Niche - drug effects; Stem Cell Niche - physiology; Tumor Microenvironment - drug effects; Tumor Microenvironment - physiology; Bone marrow; Niche; Tumorigenesis; Metastasis; Tumour microenvironment; Mesenchymal stem cells
• ISSN: 1699-048X; 1699-3055; 1699-3055
• DOI: 10.1007/s12094-011-0706-x

Over the last decade, genetic and cell biology studies have indicated that tumour growth is not only determined by malignant cancer cells themselves, but also by the tumour microenvironment. Cells present in the tumour microenvironment include fibroblasts, vascular, smooth muscle, adipocytes, immune cells and mesenchymal stem cells (MSC). The nature of the relationship between MSC and tumour cells appears dual and whether MSC are proor anti-tumorigenic is a subject of controversial reports. This review is focused on the role of MSC and bone marrow (BM) niches in cancer.