Patterns of calcific deposits in operatively excised stenotic or purely regurgitant aortic valves and their relation to mechanical stress

Two hundred twenty-one aortic cusps from 96 patients who underwent aortic valve replacement were examined. Of all the cusps that showed any calcific deposits, 87% had calcific deposits in 1 of 2 specific patterns: a coaptation pattern, where calcific deposits occurred along the line of cusp coaptati...

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Published inThe American journal of cardiology Vol. 58; no. 3; pp. 304 - 308
Main Authors Thubrikar, Mano J., Aouad, Jaffar, Nolan, Stanton P.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.08.1986
Elsevier
Subjects
Aged
Aortic Valve - pathology
Aortic Valve Insufficiency - complications
Aortic Valve Insufficiency - pathology
Aortic Valve Insufficiency - surgery
Aortic Valve Stenosis - complications
Aortic Valve Stenosis - pathology
Aortic Valve Stenosis - surgery
Biological and medical sciences
Calcinosis - etiology
Calcinosis - pathology
Cardiology. Vascular system
Endocardial and cardiac valvular diseases
Female
Heart
Humans
Male
Medical sciences
Middle Aged
Stress, Mechanical
Heart
Human
Surgical specimen
Etiopathogenesis
Cardiovascular disease
Narrowing
Aortic valve disease
Aortic regurgitation
Pathology
Cardiac valvular disease
Surgery
Calcification
Aortic valve
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Summary:Two hundred twenty-one aortic cusps from 96 patients who underwent aortic valve replacement were examined. Of all the cusps that showed any calcific deposits, 87% had calcific deposits in 1 of 2 specific patterns: a coaptation pattern, where calcific deposits occurred along the line of cusp coaptation, and a radial pattern, where calcific deposits occurred as spokes spread inward from the cusp attachment to the center of the cusp. This was true irrespective of the patients' sex or age, the type of disease, and the type of valve or the extent of calcific deposits. These patterns of calcific deposits relate to the area of maximal cusp flexion and, hence, maximal mechanical stress. It is therefore concluded that calcific deposits in aortic valve cusps occur in specific patterns in most cases, and that mechanical stress may be the initiating or accelerating factor in the calcification of these cusps.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0002-9149
1879-1913
DOI:10.1016/0002-9149(86)90067-6