The effect of vitamin E therapy on plasma and erythrocyte lipid peroxidation in chronic hemodialysis patients

• Published in: Clinica chimica acta Vol. 185; no. 1; pp. 109 - 112
• Main Authors: Yalçin, A.Süha, Yurtkuran, Mustafa, Dilek, Kamil, Kilinç, Ahmet, Taga, Yavuz, Emerk, Kaya
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 31.10.1989; Elsevier
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Chronic renal failure; Emergency and intensive care: renal failure. Dialysis management; Erythrocytes - metabolism; Humans; Intensive care medicine; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - therapy; Lipid Peroxidation; Malondialdehyde - blood; Medical sciences; Membrane Lipids - blood; Renal Dialysis; Vitamin E; Vitamin E - blood; Vitamin E - therapeutic use; Lipid peroxidation; Vitamin E; Chronic renal failure; Human; Extrarenal dialysis; Renal failure; Red blood cell; Lipids; α-Tocopherol; Quantitative analysis; Peroxidation; Blood plasma
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/0009-8981(89)90135-6

The effect of vitamin E therapy on plasma and erythrocyte (RBC) lipid peroxidation was investigated in patients undergoing chronic hemodialysis. Before vitamin E therapy, both plasma and RBC lipid peroxidation values of chronic hemodialysis patients were significantly higher than those of healthy controls. Treatment with vitamin E (300 mg/day) for 1 month resulted in a significant decrease of lipid peroxidation. Vitamin E therapy may be a promising approach to prevent peroxidation of membrane lipids in chronic renal failure.