Tumor necrosis factor as an adjunct to fractionated radiotherapy in the treatment of murine tumors

• Published in: International journal of radiation oncology, biology, physics Vol. 18; no. 3; pp. 555 - 558
• Main Authors: Nishiguchi, Iku, Willingham, Veronica, Milas, Luka
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.1990; Elsevier
• Subjects: Animals; Biological and medical sciences; Combined Modality Therapy; Diseases of the respiratory system; Female; Fibrosarcoma - chemically induced; Fibrosarcoma - drug therapy; Male; Mammary Neoplasms, Experimental - drug therapy; Mammary Neoplasms, Experimental - radiotherapy; Medical sciences; Methylcholanthrene; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Recombinant Proteins; Sarcoma, Experimental - drug therapy; TNF; Tumor irradiation; Tumor Necrosis Factor-alpha - therapeutic use; TNF; Tumor irradiation; Animal model; Tumor; Treatment; Radiotherapy; Tumor necrosis factor; Animal
• ISSN: 0360-3016; 1879-355X
• DOI: 10.1016/0360-3016(90)90060-W

Recombinant murine tumor necrosis factor (TNF) was investigated for its ability to increase the response of a murine mammary carcinoma to fractionated local tumor irradiation. When tumors in the leg of syngeneic mice grew to 8 mm in diameter (268 mm 3), they were exposed to 3, 4 or 5 Gy γ-rays daily for 10 days. Tumor necrosis factor was given 3 hr after each irradiation at a dose of 2 μg per mouse. Tumor growth delay was used as the endpoint. The effect of treatment with both agents combined was greater than the additive effect of the individual treatments. Tumor necrosis factor increased local tumor radiotherapy response by a factor of about 1.2, and by itself was effective in retarding the growth of both immunogenic and nonimmunogenic tumors. These experiments suggest that tumor necrosis factor in combination with radiotherapy may be beneficial for the treatment of cancer patients.