A new turn-on fluorescent probe for selective detection of glutathione and cysteine in living cells

A fluorescent probe (N-(4-methyl-2-oxo-2H-chromen-7-yl)-2,4-dinitrobenzenesulfonamide), which exhibits high selectivity to glutathione and cysteine among amino acids including sulphur-containing methionine and metal ions, was synthesized. The experiments demonstrate that the fluorescent probe is a r...

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Published inChemical communications (Cambridge, England) Vol. 49; no. 41; pp. 4640 - 4642
Main Authors Wei, Mingjie, Yin, Peng, Shen, Youming, Zhang, Lingli, Deng, Jianhui, Xue, Shanyan, Li, Haitao, Guo, Bin, Zhang, Youyu, Yao, Shouzhuo
Format Journal Article
LanguageEnglish
Published England 01.01.2013
Subjects
chemical communication
chemical reactions
Coumarins - chemistry
cysteine
Cysteine - analysis
fluorescent dyes
Fluorescent Dyes - chemistry
glutathione
Glutathione - analysis
HeLa Cells
Humans
Maleimides - chemistry
metal ions
methionine
Microscopy, Fluorescence
Sulfonamides - chemistry
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Summary:A fluorescent probe (N-(4-methyl-2-oxo-2H-chromen-7-yl)-2,4-dinitrobenzenesulfonamide), which exhibits high selectivity to glutathione and cysteine among amino acids including sulphur-containing methionine and metal ions, was synthesized. The experiments demonstrate that the fluorescent probe is a reliable and specific probe for glutathione and cysteine in living cells.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c3cc39045d