The diagnostic value of urinary transferrin compared to serum prostatic specific antigen (PSA) and prostatic acid phosphatase (PAP) in patients with prostatic cancer

Urinary transferrin, serum prostatic acid phosphatase (PAP) and prostatic-specific antigen (PSA) concentrations were measured in patients with prostatic cancer, prostatitis, benign prostatic hypertrophy (BPH) and in a control group. In contrast to recently published data it is concluded that urinary...

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Bibliographic Details
Published inClinica chimica acta Vol. 177; no. 1; pp. 77 - 80
Main Authors Dieijen-Visser, M.P.Van, Hendriks, M.W.G., Delaere, K.P.J., Gijzen, A.H.J., Brombacher, P.J.
Format Journal Article
LanguageEnglish
Published Shannon Elsevier B.V 30.09.1988
Elsevier
Subjects
Acid Phosphatase - analysis
Antigens, Neoplasm - analysis
Biological and medical sciences
Biomarkers, Tumor - urine
Humans
Male
Medical sciences
Nephrology. Urinary tract diseases
Prostate - enzymology
Prostate-Specific Antigen
Prostatic acid phosphatase
Prostatic carcinoma
Prostatic Hyperplasia - urine
Prostatic Neoplasms - diagnosis
Prostatic-specific antigen
Receiver operating characteristic curve
ROC Curve
Transferrin - urine
Tumors of the urinary system
Urinary tract. Prostate gland
Urinary transferrin
Prostatic-specific antigen
Urinary transferrin
Prostatic acid phosphatase
Prostatic carcinoma
Receiver operating characteristic curve
Human
Ferroprotein
Transferrin
Urinary system disease
Tumor associated antigen
Enzyme
Tumoral marker
Malignant tumor
Serum
Tumor
Diagnosis
Acid phosphatase
Prostate
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Summary:Urinary transferrin, serum prostatic acid phosphatase (PAP) and prostatic-specific antigen (PSA) concentrations were measured in patients with prostatic cancer, prostatitis, benign prostatic hypertrophy (BPH) and in a control group. In contrast to recently published data it is concluded that urinary transferrin is not suitable as a tumor marker for prostatic carcinoma. Receiver Operating Characteristic curves were constructed to compare the diagnostic value of the different tests at different cutoff values. Sensitivity and specificity of the urinary marker are extremely low compared to the serum markers PAP and especially PSA, making the former not suitable as an additional marker.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-8981
1873-3492
DOI:10.1016/0009-8981(88)90309-9