The effect of bombesin on basal, alpha-methyl-p-tyrosine, haloperidol, morphine, bremazocine and stress-induced prolactin secretion

Intravenously administered bombesin lowered basal PRL levels in conscious male rats and prevented the morphine, bremazocine and stress-induced PRL secretion. The same dose of bombesin had no effect on PRL levels in alpha-methyl-p-tyrosine pretreated rats and did not affect haloperidol-stimulated PRL...

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Bibliographic Details
Published inLife sciences (1973) Vol. 43; no. 21; p. 1755
Main Authors Buydens, P, Govaerts, J, Velkeniers, B, Finné, E, Vanhaelst, L
Format Journal Article
LanguageEnglish
Published Netherlands 1988
Subjects
alpha-Methyltyrosine
Analgesics - pharmacology
Animals
Benzomorphans - pharmacology
Bombesin - pharmacology
Haloperidol - pharmacology
Male
Methyltyrosines - pharmacology
Morphinans - pharmacology
Prolactin - blood
Prolactin - metabolism
Rats
Rats, Inbred Strains
Reference Values
Restraint, Physical
Stress, Psychological - blood
Tyrosine 3-Monooxygenase - antagonists & inhibitors
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Summary:Intravenously administered bombesin lowered basal PRL levels in conscious male rats and prevented the morphine, bremazocine and stress-induced PRL secretion. The same dose of bombesin had no effect on PRL levels in alpha-methyl-p-tyrosine pretreated rats and did not affect haloperidol-stimulated PRL release. These results show that bombesin given intravenously acts as an inhibitor of PRL secretion and suggests that it does not act on the lactotrope itself but rather by an increase of the inhibitory dopaminergic tone.
ISSN:0024-3205
DOI:10.1016/0024-3205(88)90488-2