Epigenetic mechanisms in Alzheimer's disease: Implications for pathogenesis and therapy

• Published in: Ageing research reviews Vol. 12; no. 4; pp. 1024 - 1041
• Main Authors: Wang, Jun, Yu, Jin-Tai, Tan, Meng-Shan, Jiang, Teng, Tan, Lan
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier 01.09.2013
• Subjects: Adult and adolescent clinical studies; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Alzheimer Disease - therapy; Animals; Biological and medical sciences; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Development. Metamorphosis. Moult. Ageing; DNA Methylation - drug effects; DNA Methylation - physiology; Drug Delivery Systems - trends; Epigenesis, Genetic - drug effects; Epigenesis, Genetic - genetics; Fundamental and applied biological sciences. Psychology; Genetic Predisposition to Disease - genetics; Genetic Therapy - trends; Humans; Internal Medicine; Medical sciences; Neurology; Organic mental disorders. Neuropsychology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Epigenetics; Aging; Therapy; Pathogenesis; Alzheimer's disease; Human; Nervous system diseases; Late; Alzheimer disease; Environmental factor; Mechanism; Cerebral disorder; Sensitivity; Treatment; Age of onset; DNA; Individual; Central nervous system disease; Predisposition; Genetics; Degenerative disease; Epigenesis; Histone; Methylation
• ISSN: 1568-1637; 1872-9649
• DOI: 10.1016/j.arr.2013.05.003

Highlights • Epigenetic mechanisms include DNA methylation, histone modifications and non-coding RNAs. • Epigenetic mechanisms translate environmental stimuli into modifications in gene expression. • Epigenetic mechanisms play a pivotal role in aging and the pathogenesis of AD. • Epigenetic therapies have promising potentials for AD treatment.