Kindling in developing rats: variability of afterdischarge thresholds with age

In the kindling model, the occurrence of afterdischarges is necessary for the development of seizures. In this study, the afterdischarge thresholds of the amygdala were determined in rats of 4 different age groups, beginning with 15-day-old suckling rats. Afterdischarges were triggered in 75% of the...

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Bibliographic Details
Published inBrain research Vol. 211; no. 1; p. 190
Main Authors Moshé, S L, Sharpless, N S, Kaplan, J
Format Journal Article
LanguageEnglish
Published Netherlands 27.04.1981
Subjects
Aging
Amygdala - growth & development
Amygdala - physiopathology
Animals
Brain - growth & development
Brain - physiopathology
Electric Conductivity
Rats
Seizures - physiopathology
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Summary:In the kindling model, the occurrence of afterdischarges is necessary for the development of seizures. In this study, the afterdischarge thresholds of the amygdala were determined in rats of 4 different age groups, beginning with 15-day-old suckling rats. Afterdischarges were triggered in 75% of the suckling rats and in all of the rats in the older age groups. The afterdischarge thresholds varied with age, being highest in the suckling group, lowest in the 35-day-old group and intermediate in the older groups. This variability of the thresholds did not correlate with the alterations in the catecholamine levels in the amygdala that occur during maturation. The failure of 25% of suckling rats to develop afterdischarges may explain why some suckling rats do not kindle.
ISSN:0006-8993
DOI:10.1016/0006-8993(81)90082-2