Chromosomal abnormalities in lymphogranulomatosis X (LgrX)/angioimmunoblastic lymphadenopathy (AILD)

• Published in: Leukemia research Vol. 11; no. 2; pp. 181 - 190
• Main Authors: Gödde-Salz, E., Feller, A.C., Lennert, K.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 1987; Elsevier Science
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Chromosome Aberrations - genetics; Chromosome Disorders; chromosomes; Female; Hematologic and hematopoietic diseases; Humans; Immunoblastic Lymphadenopathy - genetics; Karyotyping; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphocytes - drug effects; Lymphogranulomatosis X/angioimmunoblastic lymphadenopathy; Lymphomatoid Granulomatosis - genetics; Male; Medical sciences; Middle Aged; Phytohemagglutinins - pharmacology; T-cell lymphoma; Lymphogranulomatosis X/angioimmunoblastic lymphadenopathy; ILD, immunoblastic lymphadenopathy; LgrX, lymphogranulomatosis X; chromosomes; AILD, angioimmunoblastic lymphadenopathy; IBL, immunoblastic lymphoma; T-cell lymphoma; PHA, phytohaemagglutinine; FCS, fetal calf serum; Chromosomal aberration; Human; Trisomy; Immunoblastic lymphadenopathy; T-Lymphocyte; Cytogenetics; Aneuploidy; Hemopathy; Histiocytosis; Karyotype
• ISSN: 0145-2126; 1873-5835
• DOI: 10.1016/0145-2126(87)90024-5

Histologically, lymphogranulomatosis X (LgrX) is a Morbus Hodgkin-like disease which until now has been considered as an abnormal immune reaction or a prelymphoma. Chromosome analyses showed that LgrX and angioimmunoblastic lymphadenopathy (AILD) are characterized by chromosomal aberrations. Chromosome analyses of 18 cases of LgrX with sequential banding techniques showed abnormalities in 13 out of 18 cases. They were monoclonal in 7 cases. The most frequent abnormalities were trisomies of chromosomes Nos 3 and 5 and duplication of the X-chromosome. The abnormal karyotypes always appeared with normal mitosis in single or clonal cells. They were found in unstimulated and in PHA-stimulated cultures from lymph node and peripheral blood. Thus, it can be concluded that at least some cases of LgrX are monoclonal cell proliferations. An attempt is made to define the role of chromosomal abnormalities in the development of malignant lymphomas.