Platelet paroxetine binding and light therapy in winter depression

• Published in: Journal of affective disorders Vol. 29; no. 1; pp. 11 - 15
• Main Authors: Mellerup, Erling T., Errebo, Inge, Molin, Jeanne, Plenge, Per, Dam, Henrik
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.09.1993; Elsevier
• Subjects: Adult; Aged; Biological and medical sciences; Blood Platelets - chemistry; Carrier Proteins - analysis; Female; Glycoproteins - analysis; Humans; Light therapy; Male; Medical sciences; Middle Aged; Miscellaneous; Paroxetine - blood; Phototherapy; Platelet [ 3H]paroxetine binding; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Seasonal affective disorder; Seasonal Affective Disorder - drug therapy; Seasonal Affective Disorder - therapy; Serotonin - analysis; Serotonin Plasma Membrane Transport Proteins; Serotonin transporter; Treatments; Winter depression; Seasonal affective disorder; Platelet [ 3H]paroxetine binding; Serotonin transporter; Light therapy; Winter depression; Human; Mood disorder; Platelet; Binding capacity; Treatment; Serotonin; Seasonal variation; Biological transport; Depression; Phototherapy
• ISSN: 0165-0327
• DOI: 10.1016/0165-0327(93)90113-X

The effect of light therapy on serotonin uptake capacity in patients suffering from winter depressions (seasonal affective disorders) was examined indirectly by using [ 3H]paroxetine binding to determine the number of platelet serotonin transporters. In patients who responded to light therapy the number of platelet serotonin transporters decreased significantly following treatment. In contrast, patients who did not respond to light therapy were found to have a relatively low number of serotonin transporters prior to treatment, and the number did not change significantly following treatment.