Elevated serum manganese superoxide dismutase in acute leukemias

• Published in: Cancer letters Vol. 62; no. 3; pp. 211 - 215
• Main Authors: Nishiura, Tetsuo, Suzuki, Keiichiro, Kawaguchi, Tetsuo, Nakao, Hirohisa, Kawamura, Naohisa, Taniguchi, Masako, Kanayama, Yoshio, Yonezawa, Takeshi, Iizuka, Susumu, Taniguchi, Naoyuki
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 15.03.1992; Elsevier
• Subjects: acute lymphoid leukemia; acute myeloid leukemia; Biological and medical sciences; Enzyme-Linked Immunosorbent Assay; Follow-Up Studies; Hematologic and hematopoietic diseases; Humans; L-Lactate Dehydrogenase - blood; Leukemia, Myeloid, Acute - enzymology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; manganese-superoxide dismutase; Medical sciences; Monocytes - enzymology; Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology; Superoxide Dismutase - blood; manganese-superoxide dismutase; acute myeloid leukemia; acute lymphoid leukemia; Human; Enzyme; Superoxide dismutase; Malignant hemopathy; Tumoral marker; Acute lymphocytic leukemia; Acute myelocytic leukemia; Manganese
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/0304-3835(92)90098-G

We measured the serum levels of manganese-superoxide dismutase (Mn-SOD) in acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). Serum Mn-SOD level for normal subjects was 94.1 ± 23.5 ng/ml (mean ± S.D.), the levels for AML and ALL patients were 159.6 ± 77.1 ng/ml and 154.4 ± 77.0 ng/ml, respectively. The serum Mn-SOD levels were unrelated to individual intracellular Mn-SOD levels, but correlated well with serum lactate dehydrogenase values. Regression of the leukemia was accompanied by decrease in the serum level of Mn-SOD. Serum Mn-SOD may thus serve as a measure of the activity of the disease.