Characterization of the process for the biosynthesis of the actaplanin complex by Actinoplanes missouriensis

The production of the antibiotic actaplanin by Actinoplanes missouriensis was characterized in a high yielding process. The data generated, indicate that the antibiotic is synthesized during a period of declining cell mass as estimated by dry weight and viability. Further study demonstrated that the...

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Bibliographic Details
Published inJournal of fermentation technology (Osaka. 1977) Vol. 65; no. 1; pp. 85 - 89
Main Authors Huber, Floyd M., Pieper, Richard L., Tietz, Anthony J.
Format Journal Article
LanguageEnglish
Published Osaka Elsevier B.V 1987
Society of Fermentation Technology
Subjects
Antibiotics
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Production of active biomolecules
Actinomycetales
Antibiotic
Actinoplanes
Production
Bacteria
Actinomycetes
Biosynthesis
Actinoplanaceae
Fermentation
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Summary:The production of the antibiotic actaplanin by Actinoplanes missouriensis was characterized in a high yielding process. The data generated, indicate that the antibiotic is synthesized during a period of declining cell mass as estimated by dry weight and viability. Further study demonstrated that the producing culture binds actaplanin and is inhibited by the antibiotic in the soluble form.
ISSN:0385-6380
DOI:10.1016/0385-6380(87)90069-0