Translocation (3;6)(q21;p21) in acute myeloid leukemia with abnormal thrombopoiesis and basophilia

A case of acute myeloid leukemia (AML) with increased numbers of basophils and abnormal megakaryocytes was shown to have a t(3;6)(q21;p21) in the bone marrow cells. The morphology is described in detail and the case is discussed with reference to t(6;9)(p23;q34) and inv/ins(3)(q21q26) in AML. It is...

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Published inCancer genetics and cytogenetics Vol. 30; no. 2; pp. 261 - 267
Main Authors Hoyle, C.F., Sherrington, P., Hayhoe, F.G.J.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.02.1988
Elsevier Science
Subjects
Adult
Basophils - pathology
Biological and medical sciences
Bone Marrow - pathology
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 6
Genetic Markers
Hematologic and hematopoietic diseases
Humans
Karyotyping
Leukemia, Myeloid, Acute - blood
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Platelet Count
Translocation, Genetic
Chromosomal aberration
Human
Thrombopoiesis
Cytogenetics
Megakaryocyte
Abnormal chromosome
Hemopathy
Abnormal A3 chromosome
Basophilia
Abnormal «C6» chromosome
Acute myelocytic leukemia
Chromosome translocation
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Summary:A case of acute myeloid leukemia (AML) with increased numbers of basophils and abnormal megakaryocytes was shown to have a t(3;6)(q21;p21) in the bone marrow cells. The morphology is described in detail and the case is discussed with reference to t(6;9)(p23;q34) and inv/ins(3)(q21q26) in AML. It is possible that increased numbers of basophils in AML may be associated with a translocation involving 6p21-6p23.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
ISSN:0165-4608
1873-4456
DOI:10.1016/0165-4608(88)90193-8