Effect of angiotensin-converting enzyme genotype on renin-angiotensin components in hypertensives

• Published in: Clinica chimica acta Vol. 252; no. 1; pp. 33 - 39
• Main Authors: Zee, Robert Y.L., Schrader, Andew P., Morris, Brian J.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 15.08.1996; Elsevier
• Subjects: Adult; Angiotensin-converting enzyme, plasma; Angiotensinogen - blood; Angiotensinogen, plasma; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood pressure (human); Cardiology. Vascular system; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Female; Genotype; Humans; Hypertension - blood; Hypertension - genetics; Insertion/deletion polymorphism; Male; Medical sciences; Met 235 → Thr polymorphism; Middle Aged; Molecular genetics; Peptidyl-Dipeptidase A - blood; Peptidyl-Dipeptidase A - genetics; Polymerase chain reaction; Polymorphism, Genetic; Renin - blood; Renin, plasma; Renin-Angiotensin System - genetics; Polymerase chain reaction; Angiotensin-converting enzyme, plasma; Angiotensinogen, plasma; Molecular genetics; Renin, plasma; Blood pressure (human); Insertion/deletion polymorphism; Met 235 → Thr polymorphism; Human; Hypertension; Biological fluid; Enzyme; Cardiovascular disease; Glycoproteins; Prohormone; Blood plasma; Renin; Peptidyl-dipeptidase A; Angiotensinogen; Hydrolases; Peptidyl-dipeptidases; Aspartic endopeptidases; Proteinases
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/0009-8981(96)06310-3

Plasma angiotensin-converting enzyme (ACE) tracks with the deletion allele of an insertion/deletion ( I D ) polymorphism of the ACE gene. The aim of the present study was to determine plasma renin and angiotensinogen for each ACE genotype in 54 hypertensive and 96 normotensive subjects. Plasma renin was reduced by 52 ± 15 S.E.% in DD and by 24±12% in ID hypertensives when compared to II hypertensive ( P < 0.05 by one-way ANOVA), but in the normotensive subjects, renin values were similar for each genotype. Plasma angiotensinogen did not differ across ACE genotypes, but was elevated by 25 ± 3 S.E.% in hypertensives and showed a significant correlation with blood pressure. In conclusions, although renin does not differ significantly between ACE genotypes of normotensives, a reciprocal relationship may exist between plasma renin and plasma ACE in hypertensives.