Effects of platelet activating factor (PAF) and its receptor antagonist BN 52021 on isolated perfused guinea-pig heart
The cardiac effects of PAF and its antagonist BN 52021 have been investigated on the isolated perfused guinea-pig heart maintained at a constant hydrostatic perfusion pressure of 80 cm water. In this model, PAF (1 × 10 −11 to 1 × 10 −7 moles) induced a dose-dependent coronary vasoconstriction, a dec...
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Published in | Prostaglandins, leukotrienes and essential fatty acids Vol. 38; no. 3; pp. 189 - 194 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Kidlington
Elsevier Ltd
01.12.1989
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | The cardiac effects of PAF and its antagonist BN 52021 have been investigated on the isolated perfused guinea-pig heart maintained at a constant hydrostatic perfusion pressure of 80 cm water. In this model, PAF (1 × 10
−11 to 1 × 10
−7 moles) induced a dose-dependent coronary vasoconstriction, a decrease in heart rate and a fall in contractile force. BN 52021 (1 × 10
−6 to 2 × 10
−4 M) dose-dependently inhibited the vasospasm induced by PAF (1 × 10
−10 moles). BN 52021 also antagonized the decrease in coronary flow and heart rate, but not that of contractile force induced by a high dose of PAF (1 × 10
−7 moles). This dose of PAF also significantly (p < 0.001) provoked a marked release of TxB
2 but did not alter the generation of 6 Keto PGF
1α, PGE
2 or LTC
4. The PAF-induced increase in TxB
2 release was completely abolished by BN 52021. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0952-3278 1532-2823 |
DOI: | 10.1016/0952-3278(89)90071-9 |