Follow-up study of patients with panic disorder and agoraphobia with panic attacks treated with tricyclic antidepressants

One hundred and seven patients with panic disorder or agoraphobia with panic attacks were studied 1–4 years after treatment with a tricyclic antidepressant. At follow-up more than 80% of the patients remained symptomatic but fewer than half were experiencing panic attacks and only 40% were avoiding...

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Bibliographic Details
Published inJournal of affective disorders Vol. 16; no. 2; pp. 249 - 257
Main Authors Noyes, Russell, Garvey, Michael J., Cook, Brian L.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.03.1989
Elsevier
Subjects
Adult
Agoraphobia
Agoraphobia - drug therapy
Agoraphobia - psychology
Antidepressive Agents, Tricyclic - therapeutic use
Biological and medical sciences
Fear - drug effects
Female
Follow-up
Follow-Up Studies
Humans
Imipramine - therapeutic use
Male
Medical sciences
Neuropharmacology
Outcome
Panic - drug effects
Panic disorder
Pharmacology. Drug treatments
Phobic Disorders - drug therapy
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Agoraphobia
Outcome
Panic disorder
Follow-up
Human
Chemotherapy
Panic
Phobia
Statistical analysis
Treatment
Follow up study
Psychotropic
Adult
Antidepressant agent
Tricyclic compound
Behavioral disorder
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Summary:One hundred and seven patients with panic disorder or agoraphobia with panic attacks were studied 1–4 years after treatment with a tricyclic antidepressant. At follow-up more than 80% of the patients remained symptomatic but fewer than half were experiencing panic attacks and only 40% were avoiding phobic situations. Although patients with agoraphobia were more severely ill and had been ill longer than those with panic disorder, their response to tricyclics and eventual outcome was similar to that for patients with panic disorder. Panic and agoraphobic patients who had the most severe symptoms initially showed the least improvement. The results suggest that panic disorder and agoraphobia with panic attacks are variants of a single illness and that, despite its chronicity, this illness has a favorable outcome.
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SourceType-Scholarly Journals-1
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ISSN:0165-0327
1573-2517
DOI:10.1016/0165-0327(89)90080-3