Peroxidase activity at nodes of ranvier in some commonly used laboratory animals after intramuscular administration of horseradish peroxidase

During retrograde transport of intramuscularly administrated horseradish peroxidase (HRP) nodal axon segments of rabbit, rat, and mouse peripheral nerve fibers became HRP-positive and showed a striking proximodistal segregation of certain axoplasmic organelles. HRP-positive bodies and HRP-negative v...

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Bibliographic Details
Published inExperimental neurology Vol. 90; no. 1; pp. 272 - 277
Main Authors Berthold, C.-H., Mellström, A.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Inc 01.10.1985
Elsevier
Subjects
Animals
Biological and medical sciences
Cats
Fundamental and applied biological sciences. Psychology
Horseradish Peroxidase - administration & dosage
Injections, Intramuscular
Isolated neuron and nerve. Neuroglia
Peroxidases
Rabbits
Ranvier's Nodes - ultrastructure
Rodentia
Vertebrates: nervous system and sense organs
PLM
HRP
Vertebrata
Mammalia
Rat
Mouse
Enzyme
Rodentia
Rabbit
Node of Ranvier
Myelinated nerve fiber
Peroxidase
Lagomorpha
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Summary:During retrograde transport of intramuscularly administrated horseradish peroxidase (HRP) nodal axon segments of rabbit, rat, and mouse peripheral nerve fibers became HRP-positive and showed a striking proximodistal segregation of certain axoplasmic organelles. HRP-positive bodies and HRP-negative vesiculotubular membrane profiles were seen just distal and proximal to the nodal midlevel, respectively. This appearance was similar to that found earlier in HRP-transporting feline muscle nerve fibers. Some mechanisms that might explain the segregated appearance are briefly discussed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0014-4886
1090-2430
DOI:10.1016/0014-4886(85)90061-5