New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn

Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (1-2) and four known (3-6) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluat...

Full description

Saved in:
Bibliographic Details
Published inPlanta medica Vol. 77; no. 14; pp. 1648 - 1651
Main Authors Lang, Karen L, Guimaraes, Tatiana da Rosa, Machado, Vanessa Rocha, Zimmermann, Lara A, Silva, Izabella T, Teixeira, Marina R, Duran, Fernando J, Palermo, Jorge A, Simoes, Claudia M.O, Caro, Miguel S.B, Schenkel, Eloir P
Format Journal Article
LanguageEnglish
Published Germany 01.09.2011
Subjects
Brazil
Cell Line, Tumor
Cell Survival
Chromatography, High Pressure Liquid
Cucurbitaceae
Cucurbitaceae - chemistry
cucurbitacins
Cucurbitacins - chemistry
Cucurbitacins - isolation & purification
Cucurbitacins - pharmacology
cytotoxicity
Humans
Medicine, Traditional
Molecular Structure
nuclear magnetic resonance spectroscopy
Plant Extracts - chemistry
Plant Roots - chemistry
Plants, Medicinal
roots
Spectrometry, Mass, Electrospray Ionization
Brazil
Online AccessGet more information

Cover

More Information
Summary:Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (1-2) and four known (3-6) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluated against RD, KB, HCT-8, and A549 cell lines showing strong activity.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-0030-1270962