Primary gastric T-cell lymphoma of suppressor-cytotoxic (CD8+) phenotype: Discordant expression of T-cell receptor subunit βF1, CD7, and CD3 antigens

• Published in: Human pathology Vol. 21; no. 8; pp. 872 - 874
• Main Authors: Banerjee, Diponkar, Walton, John C., Jory, Thomas A., Crukley, Catherine, Meek, Margaret
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.1990
• Subjects: Aged; Antigens, CD19; Antigens, CD20; Antigens, CD7; Antigens, Differentiation, B-Lymphocyte - metabolism; Antigens, Differentiation, T-Lymphocyte - metabolism; CD3 Complex; CD4 Antigens - metabolism; CD8 Antigens; Female; Fluorescent Antibody Technique; gastric; Gene Expression; Humans; immunophenotyping; lymphoma; Lymphoma - immunology; Receptors, Antigen, T-Cell - metabolism; Receptors, Antigen, T-Cell, alpha-beta; Stomach Neoplasms - immunology; T-cell; T-cell receptor; T-Lymphocytes, Regulatory; T-cell receptor; gastric; T-cell; immunophenotyping; lymphoma
• ISSN: 0046-8177; 1532-8392
• DOI: 10.1016/0046-8177(90)90060-I

Primary gastric T-cell lymphomas are rare neoplasms, and all but one of the previously phenotyped cases have shown a helper-inducer phenotype. The present case is the second reported case of a primary gastric T-cell lymphoma of suppressor-cytotoxic phenotype. The tumor histology was similar to that described in some forms of node-based peripheral T-cell lymphomas. Phenotypic analysis revealed low expression of pan-T marker CD7, reduced expression of CD3, but higher density and frequency of expression of CD8 antigens that could be predicted on the basis of the pan-T markers. Natural killer cell (NK) related markers CD16, HNK-1 and NKH-1 were not expressed by the neoplastic cells. T-cell receptor (TCR) β subunit expression was detected on fewer cells than would have been predicted on the basis of CD3 and CD8 expression, and TCR δ chain expression was undetectable.