New sesquiterpene lactones from Glechoma hederacea L. and their cytotoxic effects on human cancer cell lines

• Published in: Planta medica Vol. 77; no. 9; pp. 955 - 957
• Main Authors: Kim, JinPyo, Lee, Iksoo, Ha, DoThi, Seo, Jeonglu, Min, ByungSun, Yoo, IckDong, Bae, KiHwan
• Format: Journal Article
• Language: English
• Published: Germany 01.06.2011
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Cell Line, Tumor; colon; cytotoxicity; Glechoma hederacea; Humans; Lactones - chemistry; Lactones - isolation & purification; Lactones - pharmacology; Lamiaceae - chemistry; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Sesquiterpenes - chemistry; Sesquiterpenes - isolation & purification; Sesquiterpenes - pharmacology; sesquiterpenoid lactones; spectroscopy
• ISSN: 0032-0943; 1439-0221
• DOI: 10.1055/s-0030-1250665

Three new sesquiterpene lactones, 1α,10β-epoxy-4-hydroxy-glechoma-5-en-olide (1), 1β,10α-epoxy-4,8-dihydroxy-glechoma-5-en-olide (2), and 1β,10α;4α,5β-diepoxy-8-methoxy-glechoman-8α,12-olide (3), were isolated from the whole plant of Glechoma hederacea, together with four known sesquiterpene lactones. The structures of the three new sesquiterpene lactones were determined by spectroscopic evidence. Cytotoxic effects of the isolated compounds were examined against MDA‐MB‐231 (breast), HCT116 (colon), SW620 (colon), and DU145 (prostate) human cancer cell lines.