Adenosine alters the vascular effects of a diacylglycerol analogue and polymyxin B

Endothelium-denuded rat aorta rings were used to study the possible relationship between protein kinase C and the mechanism of adenosine-induced smooth muscle relaxation. Adenosine (5 x 10(-4) M) partially relaxed the aortic rings contracted by either a depolarising amount of KCl (4 x 10(-2) M) or a...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 180; no. 2-3; p. 377
Main Authors Serban, D N, Macovei, C G, Brănişteanu, D D
Format Journal Article
LanguageEnglish
Published Netherlands 16.05.1990
Subjects
Adenosine - pharmacology
Animals
Aorta, Thoracic - drug effects
Diglycerides - pharmacology
Endothelium, Vascular - drug effects
Glycerides - pharmacology
In Vitro Techniques
Motor Endplate - drug effects
Muscle Contraction - drug effects
Muscle Relaxation - drug effects
Muscle, Smooth, Vascular - drug effects
Phenylisopropyladenosine - pharmacology
Polymyxin B - pharmacology
Polymyxins - pharmacology
Potassium Chloride - pharmacology
Rats
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Summary:Endothelium-denuded rat aorta rings were used to study the possible relationship between protein kinase C and the mechanism of adenosine-induced smooth muscle relaxation. Adenosine (5 x 10(-4) M) partially relaxed the aortic rings contracted by either a depolarising amount of KCl (4 x 10(-2) M) or activation of protein kinase C with 1-oleoyl-2-acetyl-sn-glycerol (10(-6) M). The same amount of adenosine blocked the further relaxation obtained in the presence of polymyxin B (5 x 10(-5) M), a protein kinase C blocking agent. These results suggest a possible interaction in vascular smooth muscle between adenosine and protein kinase C.
ISSN:0014-2999
DOI:10.1016/0014-2999(90)90326-2