Complementary hydrogen bonding interaction triggered co-assembly of an amphiphilic peptide and an anti-tumor drug

We report a new tumor-targeting amphiphilic peptide that can form complementary hydrogen bonds with anti-tumor drug methotrexate (MTX), leading to reversible self-assembled morphology transition from loose micelles to densely packed nanorods or nanofibers. The MTX loaded nanorods can target tumor ce...

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Published inChemical communications (Cambridge, England) Vol. 51; no. 32; pp. 6936 - 6939
Main Authors Cheng, Hong, Cheng, Yin-Jia, Bhasin, Sushant, Zhu, Jing-Yi, Xu, Xiao-Ding, Zhuo, Ren-Xi, Zhang, Xian-Zheng
Format Journal Article
LanguageEnglish
Published England 25.04.2015
Subjects
Animals
Antineoplastic Agents - chemistry
Cercopithecus aethiops
COS Cells
Drugs
HeLa Cells
Humans
Hydrogen Bonding
Hydrogen bonds
Hydrophobic and Hydrophilic Interactions
Methotrexate
Methotrexate - chemistry
Models, Molecular
Molecular Conformation
Nanofibers
Nanofibers - chemistry
Nanorods
Peptides
Peptides - chemistry
Toxicity
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Summary:We report a new tumor-targeting amphiphilic peptide that can form complementary hydrogen bonds with anti-tumor drug methotrexate (MTX), leading to reversible self-assembled morphology transition from loose micelles to densely packed nanorods or nanofibers. The MTX loaded nanorods can target tumor cells and show more than 2-fold higher cytotoxicity (IC50 = 0.38 mg L(-1)) than that towards normal cells (IC50 = 0.89 mg L(-1)).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc00501a