The gut-brain peptide cyclo(His-Pro) is secreted in a pulsatile fashion in fasting humans

• Published in: Neuropeptides (Edinburgh) Vol. 26; no. 4; pp. 273 - 280
• Main Authors: Herminghuysen, D., Cook, C., Thompson, H., Bostick, D., Lee, F., Stokes, L., Hilton, C., Prasad, C.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.04.1994; Elsevier
• Subjects: Adult; Biological and medical sciences; Fasting - physiology; Female; Humans; Male; Medical sciences; Metabolic diseases; Obesity; Peptides, Cyclic - metabolism; Periodicity; Piperazines - metabolism; Human; Obesity; Fasting; Pulsatile; Secretion; Dipeptides; Cyclo(his-pro); Neuropeptide; Nutritional status

Histidyl-proline diketopiperazine (CHP) is a cyclic dipeptide that is found in many animal tissues, most notably brain and gut. It has been found to have a variety of biologic actions and has been postulated to play a role in appetitive behavior and energy metabolism. This study was conducted in ord...