The gut-brain peptide cyclo(His-Pro) is secreted in a pulsatile fashion in fasting humans

Histidyl-proline diketopiperazine (CHP) is a cyclic dipeptide that is found in many animal tissues, most notably brain and gut. It has been found to have a variety of biologic actions and has been postulated to play a role in appetitive behavior and energy metabolism. This study was conducted in ord...

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Published inNeuropeptides (Edinburgh) Vol. 26; no. 4; pp. 273 - 280
Main Authors Herminghuysen, D., Cook, C., Thompson, H., Bostick, D., Lee, F., Stokes, L., Hilton, C., Prasad, C.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.04.1994
Elsevier
Subjects
Adult
Biological and medical sciences
Fasting - physiology
Female
Humans
Male
Medical sciences
Metabolic diseases
Obesity
Peptides, Cyclic - metabolism
Periodicity
Piperazines - metabolism
Human
Obesity
Fasting
Pulsatile
Secretion
Dipeptides
Cyclo(his-pro)
Neuropeptide
Nutritional status
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Summary:Histidyl-proline diketopiperazine (CHP) is a cyclic dipeptide that is found in many animal tissues, most notably brain and gut. It has been found to have a variety of biologic actions and has been postulated to play a role in appetitive behavior and energy metabolism. This study was conducted in order to characterize the secretory pattern of CHP during a 24 h fast. Four subjects (2 obese and 2 lean) were studied during the latter 24 h of a 36 h fast. Blood was sampled every 10–15 min and assayed for CHP concentration using a specific radioimmunoassay. Analysis revealed that circulating CHP oscillates in humans and that diurnal variation occurred but only in the obese subjects.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0143-4179
1532-2785
DOI:10.1016/0143-4179(94)90082-5