Dcr1 Tracked Down

RNAi is essential for pericentromeric heterochromatic formation in S. pombe, and although Dcr1, the initiator protein of this process, has been biochemically well described, its subcellular localization has remained elusive. In this issue of Developmental Cell, Emmerth et al. now show that Dcr1 is d...

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Bibliographic Details
Published inDevelopmental cell Vol. 18; no. 1; pp. 6 - 7
Main Authors Kaaij, Lucas J.T., Ketting, René F.
Format Journal Article
LanguageEnglish
Published Cambridge, MA Elsevier Inc 19.01.2010
Cell Press
Subjects
Active Transport, Cell Nucleus - genetics
Animals
Biological and medical sciences
Cell differentiation, maturation, development, hematopoiesis
Cell Nucleus - genetics
Cell Nucleus - metabolism
Cell physiology
Cytoplasm - genetics
Cytoplasm - metabolism
Fundamental and applied biological sciences. Psychology
Heterochromatin - genetics
Humans
Intracellular Signaling Peptides and Proteins - genetics
Molecular and cellular biology
Nuclear Pore - genetics
Nuclear Pore - metabolism
Protein Transport
Ribonuclease III - genetics
Ribonuclease III - metabolism
RNA Interference - physiology
Schizosaccharomyces - genetics
Schizosaccharomyces - metabolism
Development
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Summary:RNAi is essential for pericentromeric heterochromatic formation in S. pombe, and although Dcr1, the initiator protein of this process, has been biochemically well described, its subcellular localization has remained elusive. In this issue of Developmental Cell, Emmerth et al. now show that Dcr1 is dynamically shuttling between nucleus and cytoplasm, adding new insight into the subcellular mechanics of RNAi.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Commentary-1
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2010.01.001