Immunohistochemical and ultrastructural study of unusual IgM lambda lymphoplasmacytic tumor of the lacrimal gland

A 72-year-old man developed a slowly enlarging mass involving the left lacrimal gland. Excisional biopsy disclosed a lymphoplasmacytoid tumor which was found by immunohistochemistry techniques to be a monoclonal proliferation, expressing cytoplasmic IgM lambda. However, serum protein immunoelectroph...

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Bibliographic Details
Published inAmerican journal of ophthalmology Vol. 101; no. 4; p. 451
Main Authors Shields, J A, Cooper, H, Donoso, L A, Augsburger, J J, Arbizo, V
Format Journal Article
LanguageEnglish
Published United States 15.04.1986
Subjects
Aged
Eye Neoplasms - pathology
Humans
Immunochemistry
Lacrimal Apparatus Diseases - pathology
Lymphoma - ultrastructure
Male
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Summary:A 72-year-old man developed a slowly enlarging mass involving the left lacrimal gland. Excisional biopsy disclosed a lymphoplasmacytoid tumor which was found by immunohistochemistry techniques to be a monoclonal proliferation, expressing cytoplasmic IgM lambda. However, serum protein immunoelectrophoresis disclosed a monoclonal spike in the gamma-globulin region with IgG lambda. The patient was still systemically well with no evidence of lymphoma almost ten years after the initial recognition of the lacrimal gland mass. This unusual case demonstrated the difficulty of classifying orbital lymphoid tumors and the problems of accurately predicting the clinical course and prognosis in affected patients.
ISSN:0002-9394
DOI:10.1016/0002-9394(86)90646-X