Bilayers containing calcium ionophore A23187 form channels

For the first time, based on bilayer membrane conductance experiments, it has been shown that A23187, a carboxylic calcium ionophore, incorporated in lipid bilayers gives single channel currents similar to the well known gramicidin channel. The current characteristics indicate the possibility that t...

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 189; no. 2; pp. 1038 - 1042
Main Authors Balasubramanian, S.V., Sikdar, S.K., Easwaran, K.R.K.
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 15.12.1992
Elsevier
Subjects
Artificial membranes and reconstituted systems
Biological and medical sciences
Calcimycin - chemistry
Electric Conductivity
Electrophysiology - methods
Fundamental and applied biological sciences. Psychology
Ion Channels
Lipid Bilayers
Membrane physicochemistry
Membrane Potentials
Models, Biological
Molecular biophysics
Phosphatidylcholines - chemistry
Aggregation
Calcium
Membrane transport
Ion transport
Ionic channel
Ionophore
Bilayer
Mechanism
Carrier protein
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Summary:For the first time, based on bilayer membrane conductance experiments, it has been shown that A23187, a carboxylic calcium ionophore, incorporated in lipid bilayers gives single channel currents similar to the well known gramicidin channel. The current characteristics indicate the possibility that the transmembrane ion transport by this important calcium ionophore is initially by a carrier mechanism but with time is by a channel or pore mechanism due to the aggregation of the molecule in a lipid matrix.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(92)92308-K