Acute noise stress, ACTH administration, and blood pressure alteration

Two groups of male Wistar rats were submitted to a single noise exposure (2640 Hz, 30 W, 102 dB, 15 min) (St group) or to a single dose of ACTH (1.5 IU/100 g b.wt.) (Ac group), respectively. A control group of nontreated rats (Co group) was used. Blood pressure (BP) was measured using an indirect ta...

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Bibliographic Details
Published inPhysiology & behavior Vol. 51; no. 6; p. 1201
Main Authors Gamallo, A, Alario, P, Gonzalez-Abad, M J, Villanua, M A
Format Journal Article
LanguageEnglish
Published United States 01.06.1992
Subjects
Adrenocorticotropic Hormone - pharmacology
Animals
Blood Pressure - drug effects
Corticosterone - blood
Hematocrit
Hydrogen-Ion Concentration
Hypertension - physiopathology
Male
Noise - adverse effects
Rats
Rats, Inbred Strains
Stress, Psychological - physiopathology
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Summary:Two groups of male Wistar rats were submitted to a single noise exposure (2640 Hz, 30 W, 102 dB, 15 min) (St group) or to a single dose of ACTH (1.5 IU/100 g b.wt.) (Ac group), respectively. A control group of nontreated rats (Co group) was used. Blood pressure (BP) was measured using an indirect tail cuff method and corticosterone (B) levels were measured by specific RIA. Haematocrit (Hc) and blood pH values were also evaluated. Acute treatments of both noise exposure and ACTH administration produced corticosterone hypersecretion and blood pressure elevation, with lower haematocrit and higher blood pH values than those found in the Co group. No differences were found between St and Ac treatments.
ISSN:0031-9384
DOI:10.1016/0031-9384(92)90309-P