Non-mutagenicity of 27 aliphatic acrylate esters in the Salmonella-microsome test

The mutagenicity of 27 acrylate esters was assessed in the Salmonella-microsome assay. Methyl, ethyl, butyl, t-butyl, pentyl, neopentyl, hexyl acrylate and methacrylate and 2-hydroxyethyl methacrylate were tested; furthermore ethanediol, butanediol, pentanediol, neopentanediol, hexanediol and diethy...

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Bibliographic Details
Published inMutation Research/Genetic Toxicology Vol. 137; no. 2; pp. 95 - 102
Main Authors Waegemaekers, T.H.J.M., Bensink, M.P.M.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.08.1984
Subjects
Acrylates - toxicity
Animals
Biotransformation
Esters
Microsomes, Liver - metabolism
Mutagenicity Tests
Mutagens
Mutation
Rats
Salmonella typhimurium - drug effects
Species Specificity
Structure-Activity Relationship
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Summary:The mutagenicity of 27 acrylate esters was assessed in the Salmonella-microsome assay. Methyl, ethyl, butyl, t-butyl, pentyl, neopentyl, hexyl acrylate and methacrylate and 2-hydroxyethyl methacrylate were tested; furthermore ethanediol, butanediol, pentanediol, neopentanediol, hexanediol and diethyleneglycol diacrylate and dimethacrylate. None of these 27 acrylate esters appeared to be mutagenic in the standard Ames assay with TA1535, TA1537, TA1538, TA98 and TA100, both with and without Aroclor 1254 or phenobarbital-induced S9 mix. A liquid incubation assay of methyl methacrylate, methyl, butyl and hexyl acrylate with TA100 neither gave any indication of a mutagenic activity of these compounds.
ISSN:0165-1218
0027-5107
DOI:10.1016/0165-1218(84)90097-1