First report on bio-catalytic N-formylation of amines using ethyl formate

A bio-catalyzed N-formylation reaction of different amines has been developed using ethyl formate as a formylating agent. This protocol provides a facile and convenient strategy featuring mild reaction conditions, high efficacy, a broad substrate scope and recyclability of lipase. This method also w...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 53; no. 15; pp. 2382 - 2385
Main Authors Patre, Rupesh E., Mal, Sanjib, Nilkanth, Pankaj R., Ghorai, Sujit K., Deshpande, Sudhindra H., El Qacemi, Myriem, Smejkal, Tomas, Pal, Sitaram, Manjunath, Bhanu N.
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 2017
Subjects
Amines
Chemistry
Chemistry, Multidisciplinary
Effectiveness
Formates
Lipase
Physical Sciences
Recyclability
Science & Technology
Strategy
Substrates
ALCOHOLS
ORGANIC-SYNTHESIS
MILD CONDITIONS
ENZYMES
FORMANILIDES
SECONDARY-AMINES
DERIVATIVES
TRANSFORMATIONS
ACID ESTERS
BIOCATALYSIS
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Summary:A bio-catalyzed N-formylation reaction of different amines has been developed using ethyl formate as a formylating agent. This protocol provides a facile and convenient strategy featuring mild reaction conditions, high efficacy, a broad substrate scope and recyclability of lipase. This method also works on a large scale in high yield.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc07679c