Plasma cholesteryl ester transfer in patients with non-insulin dependent diabetes mellitus

• Published in: Clinica chimica acta Vol. 231; no. 1; pp. 29 - 38
• Main Authors: Sutherland, Wayne H., Walker, Robert J., Lewis-Barned, Nicholas J., Pratt, Helen, Tillman, Hans C.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 01.11.1994; Elsevier
• Subjects: Adult; Aged; Biological and medical sciences; Carrier Proteins - blood; Cholesterol Ester Transfer Proteins; Cholesteryl ester transfer; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Glucose - pharmacokinetics; Glycaemia; Glycoproteins; Humans; Insulin - pharmacology; Lipid Metabolism; Lipids - blood; Lipoproteins - blood; Male; Medical sciences; Middle Aged; Triglycerides - blood; Cholesteryl ester transfer; Glycaemia; Diabetes; Endocrinopathy; Human; Biological transport; Lipoprotein; Non insulin dependent diabetes; Cholesterol; Glycemia
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/0009-8981(94)90251-8

Plasma newly synthesised cholesteryl ester transfer (NCET) rates from high density lipoproteins (HDL) to very low density lipoproteins (VLDL) and low density lipoproteins (LDL) were measured in 26 patients with non-insulin dependent diabetes mellitus (NIDDM), 26 healthy subjects with closely matching plasma triglyceride (TG) levels and 10 normolipidaemic healthy individuals. In addition, insulin mediated glucose uptake was measured in the NIDDM patients and the normolipidaemic subjects. Rates of NCET were significantly ( P < 0.05) elevated in NIDDM patients compared with healthy normolipidaemic individuals but were similar to rates in healthy subjects with closely matching TG levels. In all groups of subjects plasma NCET was significantly ( P < 0.001) correlated with plasma TG concentration. In NIDDM patients correlations between NCET and plasma glucose ( r = 0.489, P = 0.011) independently of plasma TG levels, and glycated haemoglobin levels ( r = 0.430, P = 0.028) were also recorded. Insulin mediated glucose uptake was unrelated to plasma NCET rates in the study. These data suggest that in NIDDM patients under good diabetic control elevated plasma NCET rates are mainly due to hypertriglyceridaemia and a specific and possibly stimulatory effect of diabetes on these rates may be seen only in patients with poorly controlled diabetes.