Serotonin mediates cardiovascular responses to acetylcholine, bradykinin, angiotensin II and norepinephrine in the lateral septal area of the rat brain

The infusion of acetylcholine, bradykinin, angiotensin II, norepinephrine and serotonin into the lateral septal area produced a dose-dependent increase of arterial blood pressure and heart rate. A pattern of inhibition of these cardiovascular responses, produced by pretreatment of the lateral septal...

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Published inNeuropharmacology Vol. 26; no. 6; p. 561
Main Authors Pirola, C J, Scheucher, A, Balda, M S, Dabsys, S M, Finkielman, S, Nahmod, V E
Format Journal Article
LanguageEnglish
Published England 01.06.1987
Subjects
5,7-Dihydroxytryptamine - pharmacology
Acetylcholine - pharmacology
Angiotensin II - pharmacology
Animals
Bradykinin - pharmacology
Hemodynamics - drug effects
Hydroxydopamines - pharmacology
Male
Neuropeptides - antagonists & inhibitors
Neuropeptides - pharmacology
Neurotransmitter Agents - antagonists & inhibitors
Neurotransmitter Agents - pharmacology
Norepinephrine - pharmacology
Oxidopamine
Rats
Rats, Inbred Strains
Septum Pellucidum - drug effects
Septum Pellucidum - physiology
Serotonin - physiology
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Summary:The infusion of acetylcholine, bradykinin, angiotensin II, norepinephrine and serotonin into the lateral septal area produced a dose-dependent increase of arterial blood pressure and heart rate. A pattern of inhibition of these cardiovascular responses, produced by pretreatment of the lateral septal area with phentolamine, 6-hydroxydopamine, methysergide and 5,7-dihydroxytryptamine was disclosed. These results suggest that the effects of acetylcholine, bradykinin and partially of angiotensin II, depend on the release of norepinephrine and the actions of this neurotransmitter in turn depend on the integrity of the serotonergic system in the lateral septal area.
ISSN:0028-3908
DOI:10.1016/0028-3908(87)90148-1