Computer-Aided Design of Novel Siderophores: Pyridinochelin

Pyridinochelin, a novel tetradentate catecholate-type siderophore, has been designed on the basis of the active analog enterobactin and was then synthesized. Growth promotion tests indicate that this synthetic siderophore feeds various pathogenic bacteria most effectively with iron even though it la...

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Published inZeitschrift für Naturforschung C. A journal of biosciences Vol. 56; no. 7; pp. 540 - 546
Main Authors Meyer, Michael, Schnurre, Rüdiger, Reissbrodt, Rolf, Trowitzsch-Kienast, Wolfram
Format Journal Article
LanguageEnglish
Published Germany Verlag der Zeitschrift für Naturforschung 01.07.2001
Subjects
Bacteria - drug effects
Bacteria - growth & development
Catecholate-Type Siderophore
Catechols
Computer Simulation
Drug Design
Iron Transport
Models, Molecular
Molecular Conformation
Molecular Modelling
Siderophores - chemical synthesis
Siderophores - chemistry
Siderophores - pharmacology
Software
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Summary:Pyridinochelin, a novel tetradentate catecholate-type siderophore, has been designed on the basis of the active analog enterobactin and was then synthesized. Growth promotion tests indicate that this synthetic siderophore feeds various pathogenic bacteria most effectively with iron even though it lacks one catecholate group compared to enterobactin. The superposition of the mentioned siderophore structures suggests that the structure of the skeleton connecting the catecholate groups might be an important factor for the iron transport
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0939-5075
1865-7125
DOI:10.1515/znc-2001-7-811