Lymphoproliferative responses to synthetic peptides from merozoite ring-infected erythrocyte surface antigen and circumsporozoite protein: a longitudinal study during a falciparum malaria episode

Proliferative responses of peripheral blood lymphocytes to synthetic peptides representing major epitopes of two malaria antigens (the merozoite ring-infected erythrocyte surface antigen and the sporozoite circumsporozoite protein) were investigated in Madagascar during a clinical Plasmodium falcipa...

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Published inThe American journal of tropical medicine and hygiene Vol. 45; no. 5; p. 560
Main Authors Chougnet, C, Lepers, J P, Astagneau, P, Rason, M D, Savel, J, Deloron, P
Format Journal Article
LanguageEnglish
Published United States 01.11.1991
Subjects
Adolescent
Adult
Animals
Antigens, Protozoan - immunology
Antigens, Protozoan - therapeutic use
Antigens, Surface - immunology
Antigens, Surface - therapeutic use
Child
Female
Humans
Longitudinal Studies
Lymphocyte Activation - drug effects
Madagascar
Malaria, Falciparum - immunology
Malaria, Falciparum - therapy
Male
Middle Aged
Plasmodium falciparum - immunology
Protozoan Proteins
T-Lymphocytes - drug effects
Madagascar
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Summary:Proliferative responses of peripheral blood lymphocytes to synthetic peptides representing major epitopes of two malaria antigens (the merozoite ring-infected erythrocyte surface antigen and the sporozoite circumsporozoite protein) were investigated in Madagascar during a clinical Plasmodium falciparum episode. Thirty-seven patients greater than 10 years of age were enrolled at the beginning of the malaria transmission season and followed for four weeks. At enrollment, when the subjects presented with an acute infection, lymphocytes recovered from approximately 30% of them proliferated after peptide stimulation. These proliferative responses decreased sharply one and two weeks after treatment, with less than 10% responding to each peptide. Four weeks after treatment, the responses were only partially restored. The amplitude of these variations was not related to the initial parasitemia. At the individual level, proliferative response to each peptide varied greatly during the followup period, and this variation was unrelated to the presence of parasites in the blood.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.1991.45.560