Activation of CCK-A receptors induces elevation of plasma corticosterone in rats

• Published in: Peptides (New York, N.Y. : 1980) Vol. 13; no. 1; pp. 203 - 205
• Main Authors: Katsuura, Goro, Ibii, Nobuhiro, Matsushita, Akira
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 1992; Elsevier Science
• Subjects: (+)L-365,260; (−)L-364,718; Adrenals. Interrenals; Adrenocortical hormones. Regulation; Animals; Benzodiazepinones - pharmacology; Biological and medical sciences; CCK-8; CCK-A receptors; CCK-B receptors; Ceruletide; Ceruletide - pharmacology; Cholecystokinin - antagonists & inhibitors; Corticosterone - blood; Devazepide; Dose-Response Relationship, Drug; Fundamental and applied biological sciences. Psychology; Male; Phenylurea Compounds; Plasma corticosterone; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin - antagonists & inhibitors; Receptors, Cholecystokinin - metabolism; Sincalide - pharmacology; Vertebrates: endocrinology; (−)L-364,718; Plasma corticosterone; CCK-8; CCK-B receptors; Ceruletide; (+)L-365,260; CCK-A receptors; Vertebrata; Mammalia; Rat; Corticosterone; Rodentia; Adrenal hormone; Peptidergic receptor; Cholecystokinin; Glucocorticoid; Neuropeptide; Blood plasma
• ISSN: 0196-9781; 1873-5169
• DOI: 10.1016/0196-9781(92)90163-W

Cholecystokinin octapeptide (CCK-8) and ceruletide (1 μg/kg) produced a pronounced increment of plasma corticosterone levels at 30 min after intraperitoneal administration. The response to these peptides was suppressed by pretreatment with a selective antagonist for CCK-A receptors, (−)L-364,718, in a dose-related manner, but not with an antagonist for CCK-B receptors, (+)L-365,260. However, (−)L-364,718 itself had no effect on basal levels of plasma corticosterone. These results indicate that peripheral administration of CCK-8 and ceruletide stimulates the hypothalamo-pituitary adrenal axis through the activation of CCK-A receptors, but not CCK-B receptors.