Adrenocortical carcinoma: effect of hospital volume on patient outcome

• Published in: Langenbeck's archives of surgery Vol. 397; no. 2; pp. 201 - 207
• Main Authors: Lombardi, Celestino Pio, Raffaelli, Marco, Boniardi, Marco, De Toma, Giorgio, Marzano, Luigi Antonio, Miccoli, Paolo, Minni, Francesco, Morino, Mario, Pelizzo, Maria Rosa, Pietrabissa, Andrea, Renda, Andrea, Valeri, Andrea, De Crea, Carmela, Bellantone, Rocco
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.02.2012
• Subjects: Abdominal Surgery; Adolescent; Adrenal Cortex Neoplasms - mortality; Adrenal Cortex Neoplasms - pathology; Adrenal Cortex Neoplasms - surgery; Adrenalectomy - methods; Adrenalectomy - statistics & numerical data; Adrenocortical Carcinoma - mortality; Adrenocortical Carcinoma - pathology; Adrenocortical Carcinoma - surgery; Adult; Aged; Aged, 80 and over; Analysis of Variance; Cardiac Surgery; Child; Cross-Sectional Studies; Female; General Surgery; Hospitals - utilization; Humans; Kaplan-Meier Estimate; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Invasiveness - pathology; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - therapy; Neoplasm Staging; Original Article; Prognosis; Quality of Health Care; Statistics, Nonparametric; Survival Analysis; Thoracic Surgery; Traumatic Surgery; Treatment Outcome; Vascular Surgery; Workload - statistics & numerical data; Young Adult; Patient volume; Oncologic outcome; Adrenal tumor; Adrenocortical carcinoma
• ISSN: 1435-2443; 1435-2451
• DOI: 10.1007/s00423-011-0866-8

Purpose Optimal management of adrenocortical carcinoma (ACC) involves a detailed diagnostic workup, radical surgery, and appropriate adjuvant therapy. However, due to the rarity of this disease, adequate expertise is necessary to ensure optimal patient care. We evaluated if the experience of a treating center influences the outcome of ACC. Methods Two hundred sixty-three patients who underwent adrenalectomy for ACC were included in a multi-institutional surgical survey and divided into 2 groups: “high-volume center” (HVC) (≥10 adrenalectomies for ACC) and “low-volume center” (LVC) (<10 adrenalectomies for ACC). A comparative analysis was performed. Results One hundred seventy-two patients underwent adrenalectomy at HVC and 91 at LVC. The two groups were homogeneous for age, sex, clinical presentation, and stage. The mean lesions size of ACC was higher in HVC than in LVC (104.1 ± 54.6 vs 82.8 ± 41.3 mm; P  < 0.001). A significantly higher rate of lymph node dissection ( P  < 0.01) and of multiorgan resection ( P  < 0.01) was accomplished in HVC. The number of patients who underwent adjuvant therapy was significantly higher in HVC ( P  < 0.001). Local recurrence rate was lower in patients treated at HVC (6% vs 18.5%; P  = NS). Mean time to recurrence was significantly longer in HVC than in LVC (25.2 ± 28.1 vs 10.1 ± 7.5; P  < 0.01). Conclusion The expertise of dedicated centers had a positive impact on the outcome of patients with ACC, resulting in a lower recurrence rate and improved mean time to recurrence. The improved patient outcome could be related not only to the appropriateness of the surgical procedure, but also to a more adequate multidisciplinary approach.